Provigil 100mg Tablets

What is Provigil 100mg?

Provigil 100mg tablet is used to enhance wakefulness in people those are too sleepy due to narcolepsy or obstructive sleep apnea & daytime sleepiness due to shift work sleep disorder. Provigil 100mg is a generic variation of Modafinil approved by FDA in the year 2005 in US & 2014 in UK & EU. Its mechanism of action is to treat patients who are unable to stay awake throughout the day.

The IUPAC name for provigil 100mg is  (diphenylmethanesulfinyl) acetamide.  Its chemical formula is  C15H15NO2S and its molecular weight is 273.35. Provigil is classified as BCS category II, which has low solubility and high permeability. Modafinil is moderately bound to plasma proteins, with approximately 60% to 63% binding. It is primarily metabolised in the liver by the cytochrome P450 enzyme system, primarily the CYP3A4 and CYP2B6 enzymes.

The half-life of Provigil 100mg is approximately 12 to 15 hours in most individuals.

What are The Uses of Provigil 100mg Tablets?

Provigil 100mg is a stimulant contains Modafinil as an active ingredient used to keep people awake those are with excessive sleepiness due to narcolepsy, obstructive sleep apnea & shift work sleep disorder. It can be helpful with various sleep problems or conditions. Some of them are given below.

• Narcolepsy is a condition where patients suffer from excessive sleepiness throughout the day and have quick episodes of muscle weakness and sleep attacks. All these symptoms are treated by Provigil 100mg.
• This medication helps with less sleepiness and helps stay awake for patients who have obstructive sleep apnea (OSA).
• It is possible to treat shift work sleep disorder (SWSD) with provigil 100 mg. The person has this condition when they work odd shifts and find it hard to keep their sleep-wake cycle normal.
• This medication can be used off-label too.
• Jet lag , sleep problems, ADHD, depression, cognitive enhancement, and chronic fatigue syndrome are some conditions where it can be used off label.

What are The Dosage Guidelines for Provigil 100mg Tablets?

Find the dosage guidelines based on narcolepsy, obstructive sleep apnea & shift work sleep disorder given as below;

• Narcolepsy and Obstructive Sleep Apnea (OSA)

The typical dosage of Provigil for narcolepsy or OSA is 100 to 200mg taken orally once daily in the morning.

Healthcare providers may initiate treatment with a lower dosage of 100mg and titrate upward based on individual response and tolerability.

• Shift Work Sleep Disorder (SWSD)

For individuals with SWSD, Provigil is typically taken as a single dose of 100mg to 200mg approximately one hour before the start of the work shift.

The medication should be administered orally, with or without food.

• Dosage adjustments are necessary based on patients’ responses and behaviours.
• This medication should be used under the proper guidance of the healthcare provider.

How do I Take A Provigil 100mg Tablet?

• Swallow the Provigil 100mg tablet whole with a full glass of water.
• Take it orally in the morning, with or without food.
• Maintain consistent timing daily for optimal effectiveness.
• Avoid alcohol consumption and attend follow-up appointments regularly.

Missed Dosage Guidelines:

• The missed dose should be skipped and the regular dosage should be resumed. 
• It’s important not to double up on doses to make up for a missed one, as this can increase the risk of adverse effects. 

Overdosage Guidelines:

• If someone has consumed more than the prescribed amount, they should seek medical assistance or contact a poison control centre.
• A provigil overdose can cause agitation, disorientation, hallucinations, a fast heartbeat, perspiration, nausea, vomiting, and seizures, among other symptoms. Must be closely supervised
• Should visit the nearest emergency services as soon as possible if a person has overdosed on the drug.
• Do not attempt to treat a Provigil overdose at home without medical supervision, as it can increase the risk of complications 
• Provide healthcare providers with information about the amount of Provigil ingested, the time of ingestion, and any other medications or substances taken concurrently.
• Keep Provigil out of the reach of minors and anyone else who might abuse or inadvertently consume the drug to avoid accidental overdosing.

Guidelines to Buy Prescription (Schedule IV Controlled Substance) Drugs Online:

One drug used to treat both obstructive sleep apnea and narcolepsy is Provigil 100 mg. It is a drug that is controlled under Schedule IV. Therefore, in the United States of America (USA), the United Kingdom (UK), Europe (EU), and Australia (AU), a prescription is required in order to purchase these prescriptions online. Thus, purchase 100 mg Provigil tablets in the USA, UK, EU, AU, and Australia only if you have a prescription for this drug. We offer free pills, free shipping, a low price guarantee, and safe payment options like credit card, debit card, ZellePay, bitcoin, etc. for Provigil 100 mg tablets.

How does The Provigil 100mg Tablet Work?

The provigil mechanism of action is still fully understood but it has the ability to make you more awake.

It works by changing the brain’s chemical systems, mostly those that deal with dopamine, norepinephrine, histamine, and orexin/hypocretin. 

Pharmacodynamics:

• Provigil changes the release and absorption of neurotransmitters, mainly dopamine and norepinephrine, in important parts of the brain that control sleepiness. Provigil makes you more alert and awake by increasing the release of these chemicals and blocking their reuptake.
• Orexin is a neuropeptide that helps in maintaining the sleep-wake cycle. Provigil increases the activity of orexin, which makes you more awake and less sleepy.
• Another chemical is histaminergic. Provigil boosts the transfer of histaminergic neurotransmitters, which are chemicals that keep you awake

Pharmacokinetics:

• Provigil is rapidly absorbed after oral administration, reaching peak plasma concentrations within 2 to 4 hours.
• It undergoes hepatic metabolism primarily via the cytochrome P450 enzyme system, mainly CYP3A4 and CYP2B6.
• The elimination half-life of Provigil is approximately 12 to 15 hours. It mostly leaves the body in the urine, with only a small amount of unchanged drug leaving the body.

What are The Side Effects of Provigil 100mg Tablets?

Severe Allergic Reactions:

It is very rare for a person  who takes Provigil to have severe allergic reactions like angioedema and anaphylaxis. Face, lips, tongue, or throat swelling, trouble breathing, and a rash are some of the side effects. 

Effects on Psychiatric Conditions:

Mental health conditions such as anxiety, agitation, hallucinations, or suicidal thoughts may get worse or emerge as a result of taking Provigil. Provigil users should be closely observed for any behavioural or emotional changes.

Cardiovascular Effects:

Provigil may cause an increase in heart rate and blood pressure, particularly in those who are predisposed to cardiac issues. You should exercise caution and get your blood pressure checked if you take Provigil along with heart medications.

Problems with the Liver:

Provigil users have experienced significant liver damage, including hepatocellular necrosis. Individuals who have liver disease should be closely monitored for symptoms such as elevated liver enzymes, stomach pain, or jaundice.

Stevens-Johnson Syndrome:

Stevens-Johnson syndrome is an extremely severe skin reaction that very few Provigil users have reported having. Blisters, peeling skin, and rash are a few symptoms.

Precautions & Warnings:

• People who have arterial disease, such as high blood pressure, arrhythmias, or ischemic heart disease, need to be treated carefully.
• Patients with psychosis, depression, need to have their symptoms checked on a regular basis.
• Those who have a history of addiction are more likely to abuse and become dependent on Provigil.
• Because the liver controls most of the metabolism, you should take precautions for people who have a lot of liver problems.
• Renal excretion may require you to adjust your dosage if you have severe renal impairment.
• Because older people are more sensitive, they may need smaller doses of Provigil.
• Physicians advise patients to limit or avoid alcohol while taking Provigil.  
• People who are known to be hypersensitive should not take Provigil 

Interactions:

Adverse effects of Provigil 150 mg:

• Provigil reduces the effectiveness of hormonal birth control due to liver enzyme induction.
• Some antifungal drugs suppress the breakdown of Provigil, which could cause a rise in blood levels. Change the dosage in accordance with the doctor’s instructions.
• Interactions with CYP3A4 change Provigil levels, which require dosage changes for maximum efficacy.
• Careful use and dosage modifications are required because Provigil amplifies CNS depressive effects
• Because Provigil changes the effects of psychiatric drugs, patients need to be closely monitored,and their doses also need to be changed.
• Provigil raises blood pressure. It should not be taken with heart medicines and the amount of the dosage should be changed.

FAQs:

Q. What is Provigil 150 mg used for?

Provigil 150 mg is prescribed to treat excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD).

Q. What should I do if I miss a dose of Provigil 150 mg?

If you miss a dose, take it as soon as you remember. However, if it’s close to bedtime or your next scheduled dose, skip the missed dose and resume your regular dosing schedule.

Q. How long does it take for Provigil 150 mg to start working?

Provigil 150 mg usually starts working within 30 to 60 minutes after ingestion, with peak effects observed within 2 to 4 hours.

Q. Can Provigil 150 mg be taken with other medications?

Inform your healthcare provider about all medications, including over-the-counter and herbal supplements, before taking Provigil 150 mg to avoid potential interactions.

Q. Is Provigil 150 mg safe for pregnant or breastfeeding women?

Pregnant or breastfeeding women should consult their healthcare provider before taking Provigil 150 mg due to potential risks to the foetus or infant.

Q. Is Provigil 150 mg addictive?

Provigil 150 mg has a low potential for addiction or dependence when used as prescribed. However, follow your doctor’s instructions carefully to minimise risks.